Topic: Coenzyme Q 10
Coenzyme Q 10
posted Sun, 21 Sep 2003 05:32PM
Larry
I thought you would find these articlse on ScienceDirect useful.
If the link below is not active or is partially hyperlinked, copy
the entire link and paste the URL into the Address/Location box on
your browser.
Coenzyme Q10 concentrations and antioxidant status in tissues of
breast cancer patients,
Clinical Biochemistry, Volume 33, Issue 4, Pages 279-284 (June 2000)
Oytun Portakal, ÖZay Özkaya, Mine Erden inal, Berrin Bozan, MüBerra
Kosan and Iskender Sayek
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TDD-40X8D0H-6&_coverDate=06%2F30%2F2000&_alid=114487827&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5196&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a6b2078bb04cef7250444a18c724a47d
1.Cell Surface NADH Oxidases (ECTO-NOX Proteins) with Roles in Cancer, Cellular Time-keeping, Growth, Aging and Neurodegenerative Diseases
Free Radical Research, June 2003, vol. 37, no. 8, pp. 795-808(14)
James Morré D.; Morré D.M.
Abstract:
ECTO-NOX (because of their cell surface location) proteins comprise a family of NAD(P)H oxidases of plants and animals that exhibit both oxidative and protein disulfide isomerase-like activities. The two biochemical activities, hydroquinone [NAD(P)H] oxidation and protein disulfide-thiol interchange alternate, a property unprecedented in the biochemical literature. A tumor-associated ECTO-NOX (tNOX) is cancer-specific and drug-responsive. The constitutive ECTO-NOX (CNOX) is ubiquitous and refractory to drugs. The physiological substrate for the oxidative activity appears to be hydroquinones of the plasma membrane such as reduced coenzyme Q10. ECTO-NOX proteins are growth-related and drive cell enlargement. Also indicated are roles in aging and in neurodegenerative diseases. The regular pattern of oscillations appears to be related to agr-helix-bgr-structure transitions and serves biochemical core oscillator of the cellular biological clock. Period length is independent of temperature (temperature compensated) and synchrony is achieved through entrainment.
Keywords: ECTO-NOX; Coenzyme Q; Protein disulfide-thiol interchange; Cancer; Biological clock; Aging; Neurodegenerative diseases
Document Type: Research article ISSN: 1071-5762
DOI (article): 10.1080/1071576031000083107
SICI (online): 1071-5762(20030101)37:8L.795;1-
2.Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults
Clinica Chimica Acta, June 2003, vol. 332, no. 1, pp. 123-132(10)
Miles M.V.[1]; Horn P.S.; Morrison J.A.; Tang P.H.; DeGrauw T.; Pesce A.J.
[1]Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229-3030, Cincinnati, OH, USA
Abstract:
Background: Abnormal concentrations of coenzyme Q10 have been reported in many patient groups, including certain cardiovascular, neurological, hematological, neoplastic, renal, and metabolic diseases. However, controls in these studies are often limited in number, poorly screened, and inadequately evaluated statistically. The purpose of this study is to determine the reference intervals of plasma concentrations of ubiquinone-10, ubiquinol-10, and total coenzyme Q10 for self-reported healthy adults. Methods: Adults (n=148), who were participants in the Princeton Prevalence Follow-up Study, were identified as healthy by questionnaire. Lipid profiles, ubiquinone-10, ubiquinol-10, and total coenzyme Q10 concentrations were measured in plasma. The method used to determine the reference intervals is a procedure incorporating outlier detection followed by robust point estimates of the appropriate quantiles. Results: Significant differences between males and females were present for ubiquinol-10 and total coenzyme Q10. Blacks had significantly higher Q10 measures than whites in all cases except for the ubiquinol-10/total Q10 fraction. Conclusions: The fraction of ubiquinol-10/total coenzyme Q10 is a tightly regulated measure in self-reported healthy adults, and is independent of sex and racial differences. Different reference intervals for certain coenzyme Q10 measures may need to be established based upon sex and racial characteristics.
Keywords: Coenzyme Q10; Ubiquinone; Ubiquinol; Oxidative stress; Reference interval; Biomarker
Language: English Document Type: Research article ISSN: 0009-8981
DOI (article): 10.1016/S0009-8981(03)00137-2
SICI (online): 0009-89813321123132
3.results
my files
saved searches [personal users only]
marked list
shopping cart
manage my ingenta [personal users only]
track my orders [personal users only]
first FIRST back BACK document 85 of 187 FORWARD forward LAST last
mark Science Direct
Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients
Clinical Biochemistry, June 2000, vol. 33, no. 4, pp. 279-284(6)
Portakal O.[1]; Ozkaya O.; Erden inal M.; Bozan B.; Kosan M.; Sayek I.
[1]1Department of Biochemistry, The Medical School of Osmangazi University, , Eskisehir, Turkey
Abstract:
Objectives: An increasing amount of experimental and epidemiological evidence implicates the involvement of oxygen derived radicals in the pathogenesis of cancer development. Oxygen derived radicals are able to cause damage to membranes, mitochondria, and macromolecules including proteins, lipids and DNA. Accumulation of DNA damages has been suggested to contribute to carcinogenesis. It would, therefore, be advantageous to pinpoint the effects of oxygen derived radicals in cancer development.Design and methods: In the present study, we investigated the relationship between oxidative stress and breast cancer development in tissue level. Breast cancer is the most common malignant disease in Western women. Twenty-one breast cancer patients, who underwent radical mastectomy and diagnosed with infiltrative ductal carcinoma, were used in the study. We determined coenzyme Q10 (Q) concentrations, antioxidant enzyme activities (mitochondrial and total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase), and malondialdehyde (MDA) levels in tumor and surrounding tumor-free tissues.Results: Q concentrations in tumor tissues significantly decreased as compared to the surrounding normal tissues (p I thought you would find these articlse on ScienceDirect useful.
If the link below is not active or is partially hyperlinked, copy
the entire link and paste the URL into the Address/Location box on
your browser.
Coenzyme Q10 concentrations and antioxidant status in tissues of
breast cancer patients,
Clinical Biochemistry, Volume 33, Issue 4, Pages 279-284 (June 2000)
Oytun Portakal, ÖZay Özkaya, Mine Erden inal, Berrin Bozan, MüBerra
Kosan and Iskender Sayek
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TDD-40X8D0H-6&_coverDate=06%2F30%2F2000&_alid=114487827&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5196&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a6b2078bb04cef7250444a18c724a47d
1.Cell Surface NADH Oxidases (ECTO-NOX Proteins) with Roles in Cancer, Cellular Time-keeping, Growth, Aging and Neurodegenerative Diseases
Free Radical Research, June 2003, vol. 37, no. 8, pp. 795-808(14)
James Morré D.; Morré D.M.
Abstract:
ECTO-NOX (because of their cell surface location) proteins comprise a family of NAD(P)H oxidases of plants and animals that exhibit both oxidative and protein disulfide isomerase-like activities. The two biochemical activities, hydroquinone [NAD(P)H] oxidation and protein disulfide-thiol interchange alternate, a property unprecedented in the biochemical literature. A tumor-associated ECTO-NOX (tNOX) is cancer-specific and drug-responsive. The constitutive ECTO-NOX (CNOX) is ubiquitous and refractory to drugs. The physiological substrate for the oxidative activity appears to be hydroquinones of the plasma membrane such as reduced coenzyme Q10. ECTO-NOX proteins are growth-related and drive cell enlargement. Also indicated are roles in aging and in neurodegenerative diseases. The regular pattern of oscillations appears to be related to agr-helix-bgr-structure transitions and serves biochemical core oscillator of the cellular biological clock. Period length is independent of temperature (temperature compensated) and synchrony is achieved through entrainment.
Keywords: ECTO-NOX; Coenzyme Q; Protein disulfide-thiol interchange; Cancer; Biological clock; Aging; Neurodegenerative diseases
Document Type: Research article ISSN: 1071-5762
DOI (article): 10.1080/1071576031000083107
SICI (online): 1071-5762(20030101)37:8L.795;1-
2.Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults
Clinica Chimica Acta, June 2003, vol. 332, no. 1, pp. 123-132(10)
Miles M.V.[1]; Horn P.S.; Morrison J.A.; Tang P.H.; DeGrauw T.; Pesce A.J.
[1]Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229-3030, Cincinnati, OH, USA
Abstract:
Background: Abnormal concentrations of coenzyme Q10 have been reported in many patient groups, including certain cardiovascular, neurological, hematological, neoplastic, renal, and metabolic diseases. However, controls in these studies are often limited in number, poorly screened, and inadequately evaluated statistically. The purpose of this study is to determine the reference intervals of plasma concentrations of ubiquinone-10, ubiquinol-10, and total coenzyme Q10 for self-reported healthy adults. Methods: Adults (n=148), who were participants in the Princeton Prevalence Follow-up Study, were identified as healthy by questionnaire. Lipid profiles, ubiquinone-10, ubiquinol-10, and total coenzyme Q10 concentrations were measured in plasma. The method used to determine the reference intervals is a procedure incorporating outlier detection followed by robust point estimates of the appropriate quantiles. Results: Significant differences between males and females were present for ubiquinol-10 and total coenzyme Q10. Blacks had significantly higher Q10 measures than whites in all cases except for the ubiquinol-10/total Q10 fraction. Conclusions: The fraction of ubiquinol-10/total coenzyme Q10 is a tightly regulated measure in self-reported healthy adults, and is independent of sex and racial differences. Different reference intervals for certain coenzyme Q10 measures may need to be established based upon sex and racial characteristics.
Keywords: Coenzyme Q10; Ubiquinone; Ubiquinol; Oxidative stress; Reference interval; Biomarker
Language: English Document Type: Research article ISSN: 0009-8981
DOI (article): 10.1016/S0009-8981(03)00137-2
SICI (online): 0009-89813321123132
3.results
my files
saved searches [personal users only]
marked list
shopping cart
manage my ingenta [personal users only]
track my orders [personal users only]
first FIRST back BACK document 85 of 187 FORWARD forward LAST last
mark Science Direct
Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients
Clinical Biochemistry, June 2000, vol. 33, no. 4, pp. 279-284(6)
Portakal O.[1]; Ozkaya O.; Erden inal M.; Bozan B.; Kosan M.; Sayek I.
[1]1Department of Biochemistry, The Medical School of Osmangazi University, , Eskisehir, Turkey
Abstract:
Objectives: An increasing amount of experimental and epidemiological evidence implicates the involvement of oxygen derived radicals in the pathogenesis of cancer development. Oxygen derived radicals are able to cause damage to membranes, mitochondria, and macromolecules including proteins, lipids and DNA. Accumulation of DNA damages has been suggested to contribute to carcinogenesis. It would, therefore, be advantageous to pinpoint the effects of oxygen derived radicals in cancer development.Design and methods: In the present study, we investigated the relationship between oxidative stress and breast cancer development in tissue level. Breast cancer is the most common malignant disease in Western women. Twenty-one breast cancer patients, who underwent radical mastectomy and diagnosed with infiltrative ductal carcinoma, were used in the study. We determined coenzyme Q10 (Q) concentrations, antioxidant enzyme activities (mitochondrial and total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase), and malondialdehyde (MDA) levels in tumor and surrounding tumor-free tissues.Results: Q concentrations in tumor tissues significantly decreased as compared to the surrounding normal tissues (p
Implications
posted Mon, 22 Sep 2003 09:11PM
DarkLady
This is current research! We should take notice.
Has anyone any idea what the implications are for people taking statins, to reduce cholesterol? Some reports suggest that statins reduce the amount of Co Q10 in the body, hence the muscle pain. But if low levels give an opening to cancer, perhaps caution is called for.